About Me

dna-512
Science
Industry
Industry
bulb-creativity
Creativity

IMG_7965 copyI am Yi Liu, a postdoctoral researcher at University of California, Los Angeles (UCLA). I work in Alexander Hoffmann’s Lab in the new Institute of Quantitative and Computational Biology (iQCB) and Dep. of MIMG. My research focuses on how NFkB signaling system regulates the blood regeneration process in our body, either in physiological or pathological conditions. In my spare time, I lead a healthcare-sector-focused investment club. I like creative activities. I share my writings and small software tools on my portfolio of websites.

Science


Blood is one of the most regenerative tissue in our body. In any healthy individual, new blood cells are made to replace old cells in a constant basis. During infection or blood loss, this regenerative capacity is key to survival. All blood cell types came from one cell type – hematopoietic stems cells (HSCs). This process is tightly regulated and precisely balanced to maintain an ideal composition of blood.

However, while much more is understood about functions and regulations of mature blood cells (such as T, B, Dendritic cells), less is known about the regulation of hematopoiesis process: the long development big bang from HSCs to mature blood cells.

My research tackles this question from a specific angle: how a network of NFkB transcription factors dynamicly regulate this process. I utilize the unique spectrum of expertise in Alexander Hoffmann’s lab, including biochemistry, mice models, and computational modeling.

I believe we will be able to understand the big bang of blood. This will help cure diseases of the blood system, including but not limited to leukemia, anemia, lymphoma, bone marrow transplantation, survival to radiation.

Education

Publications

Industry


I joined DeepKinase in August 2021 and serves as its Chief Research Officer.

I founded and currently lead Positive Strand Investment Club (PSIC). At PSIC, we apply our diverse talents to studying biotech and pharmaceutical industry. We thrive to identify industry trends, innovative drugs, and potential investment opportunities. Learn more >>.

Creativity


Software Development

  • DeepKinase: official website for a tyrosine phosphoproteomics company
  • GapDB: check stock price gaps
  • PyHRM: Free Opensource High Resolution Melt Analysis in Python
  • iPyNbViewer: Standalone App for IPython Notebook
  • BioLog: A online log system with search filter (List.js)
  • TRIALERT: discontinued. automated clinical trial tracking
  • LoveLoveBean App: discontinued. automatically fetch, match and notify you L.L.Bean Daily Sales

Chinese Art

I learned Chinese Seal Carving from Master Li Shengshi (李盛世). I also help promote his artwork in the United States. Learn more at his website.

ChinaBlog.cc

During 2009-2010, I spent two years of spare time, wrote/edited about 200 articles about China at ChinaBlog.cc. The articles are in English, aiming to introduce China to the English speaking world. I covered a variety of topics, including Chinese Art, Music, Literature, Travel, Food, and History etc.

Other Websites

PKUBIO.org: Peking University BIO-Net Symposium: A network of Peking University alumni and friends in the field of life sciences.